Necrox-5 (methanesulfonate)

Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity. It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 µM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 µM t-BHP). This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.Formal Name: 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate. CAS Number: 1383718-29-3. Synonyms: Necrosis Inhibitor 5, NecroX-5. Molecular Formula: C25H31N3O3S . 2CH4O3S. Formula Weight: 645.8. Purity: >85%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.1 mg/ml, DMSO: 1 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 209, 275, 311 nm. SMILES: O=S(CCN1CC2=CC(NCC3CCOCC3)=C(NC(C4=CC=CC=C4)=C5)C5=C2)(CC1)=O.OS(C)(=O)=O.OS(C)(=O)=O. InChi Code: InChI=1S/C25H31N3O3S.2CH4O3S/c29-32(30)12-8-28(9-13-32)18-20-14-22-16-23(21-4-2-1-3-5-21)27-25(22)24(15-20)26-17-19-6-10-31-11-7-19,2*1-5(2,3)4/h1-5,14-16,19,26-27H,6-13,17-18H2,2*1H3,(H,2,3,4). InChi Key: ZWWWDIWEZYRVMB-UHFFFAOYSA-N.