NASPM (hydrochloride)

NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM. However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors. NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons. This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.Formal Name: N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide, trihydrochloride. CAS Number: 1049731-36-3. Synonyms: 1-Naphthylacetyl spermine. Molecular Formula: C22H34N4O . 3HCl. Formula Weight: 479.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1.7 mg/mL, PBS (pH 7.2): 10 mg/mL. lambdamax: 224, 280 nm. SMILES: O=C(NCCCNCCCCNCCCN)CC1=CC=CC2=C1C=CC=C2.Cl.Cl.Cl. InChi Code: InChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20,,,/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27),3*1H. InChi Key: JNEOJAUJWOPWJS-UHFFFAOYSA-N.