Narciclasine

Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 µM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts. Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.Formal Name: (2S,3R,4S,4aR)-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one. CAS Number: 29477-83-6. Synonyms: (+)-Lycoricidinol, (+)-Narciclasine. Molecular Formula: C14H13NO7. Formula Weight: 307.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM. SMILES: OC1=C(C(N[C@]2([H])C3=C[C@H](O)[C@@H](O)[C@H]2O)=O)C3=CC4=C1OCO4. InChi Code: InChI=1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1. InChi Key: LZAZURSABQIKGB-AEKGRLRDSA-N.