Narciclasine

Pale grey powder. Soluble in DMSO (30mg/ml). Chemical. CAS: 29477-83-6. Formula: C14H13NO7. MW: 307.3. Plant growth modulator/inhibitor. Anticancer agent. Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines. Shown to promote autophagy-induced apoptosis and to slow cell cycle progression. Inhibits protein synthesis by interacting with the 60S ribosome subunit. Regulates the Rho/ROCK/LIM kinase/cofilin pathway. Stimulates RhoA activation and induces actin polymerization. Anti-obesity agent. Attenuates diet-induced obesity (DIO) in mice by promoting oxidative metabolism in skeletal muscle and energy expenditure. Anti-inflammatory agent suppressing NF-kappaB-dependent gene transcription. Antiviral agent in vitro. Antifungal agent. Shown to inhibit amyloid plaque formation in an Alzheimer's disease model.