Nafcillin-d5 (sodium salt)

Nafcillin-d5 is intended for use as an internal standard for the quantification of nafcillin (Cay-21008) by GC- or LC-MS. Nafcillin is a semisynthetic and penicillinase-resistant penicillin antibiotic. It is active against 20 clinical isolates of S. aureus with minimum bactericidal concentration (MBC) values ranging from 0.078 to 0.312 µg/ml. Nafcillin (100-800 mg/kg) reduces the number of kidney colony forming units (CFUs) in a mouse model of S. aureus infection. It also reduces the number of right atrial CFUs in a rabbit model of S. aureus-induced endocarditis. Formulations containing nafcillin have been used in the treatment of various bacterial infections.Formal Name: (2S,5R,6R)-6-(2-(ethoxy-d5)-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, monosodium salt. CAS Number: 1356354-25-0. Molecular Formula: C21H16D5N2O5S . Na. Formula Weight: 441.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: [O-]C([C@@H]1N2[C@@](SC1(C)C)([H])[C@@H](C2=O)NC(C3=C(OC([2H])([2H])C([2H])([2H])[2H])C=CC4=C3C=CC=C4)=O)=O.[Na+]. InChi Code: InChI=1S/C21H22N2O5S.Na/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23,/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27),/q,+1/p-1/t15-,16+,19-,/m1./s1/i1D3,4D2,. InChi Key: AYAPZOUDXCDGIF-LYVUTDJTSA-M.