N-tert-butyl-alpha-Phenylnitrone

N-tert-butyl-alpha-Phenylnitrone (PBN) is a cell permeable spin trap commonly used in free radical research. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. At millimolar concentrations, PBN has been shown to inhibit LPS-induced NF-kappaB DNA binding activity and inhibits COX-2 catalytic activity.Formal Name: 2-methyl-N-(phenylmethylene)-2-propanamine N-oxide. CAS Number: 3376-24-7. Synonyms: PBN. Molecular Formula: C11H15NO. Formula Weight: 177.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 226, 294 nm. SMILES: [O-]/[N+](C(C)(C)C)=C\C1=CC=CC=C1. InChi Code: InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-. InChi Key: IYSYLWYGCWTJSG-XFXZXTDPSA-N.