N-methyl Paroxetine

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine (Cay-14998) that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin (5-HT, Cay-14332) uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.Formal Name: (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl-piperidine. CAS Number: 110429-36-2. Synonyms: Paroxetine-Related Compound F. Molecular Formula: C20H22FNO3. Formula Weight: 343.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMF:PBS (pH 7) (1:10): 0.09 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 235, 265, 271, 295 nm. SMILES: FC1=CC=C([C@H]2[C@H](COC3=CC(OCO4)=C4C=C3)CN(C)CC2)C=C1. InChi Code: InChI=1S/C20H22FNO3/c1-22-9-8-18(14-2-4-16(21)5-3-14)15(11-22)12-23-17-6-7-19-20(10-17)25-13-24-19/h2-7,10,15,18H,8-9,11-13H2,1H3/t15-,18-/m0/s1. InChi Key: MOJZPKOBKCXNKG-YJBOKZPZSA-N.