N-Deshydroxyethyl Dasatinib

Description: N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases. Target: Others, Drug Metabolite, IAP. Smiles: N(C1=CC(=NC(C)=N1)N2CCNCC2)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3. References: Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug,108(8):1657-1666.