N-Benzyl Linoleamide

N-Benzyl linoleamide is an inhibitor of soluble epoxide hydrolase (sEH, IC50s = 0.155, 0.041, and 0.044 µM for the human, rat, and mouse enzymes, respectively). It is selective for sEH over fatty acid amide hydrolase (FAAH, IC50 = 10.8 µM for the human enzyme). N-Benzyl linoleamide also inhibits the production of NF-kappaB (IC50 = 8.80 µM) and activates nuclear factor erythroid 2-related factor 2 (Nrf2, EC50 = 35.24 µM in a transactivation assay) in Neuro2a murine neuroblastoma cells. It increases the paw withdrawal threshold in a mouse model of LPS-induced inflammatory pain when administered at a dose of 100 mg/kg.Formal Name: (9Z,12Z)-N-(phenylmethyl)-9,12-octadecadienamide. CAS Number: 18286-71-0. Molecular Formula: C25H39NO. Formula Weight: 369.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(NCC1=CC=CC=C1)=O. InChi Code: InChI=1S/C25H39NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-25(27)26-23-24-20-17-16-18-21-24/h6-7,9-10,16-18,20-21H,2-5,8,11-15,19,22-23H2,1H3,(H,26,27)/b7-6-,10-9-. InChi Key: YJWLCIANOBCQGW-HZJYTTRNSA-N.