N-acetyl-L-Cysteine amide

N-acetyl-L-Cysteine amide (NACA) is an antioxidant. It is the amide form of N-acetyl-L-cysteine (NAC, Cay-20261) and has increased cellular membrane and blood-brain barrier permeability compared to NAC. NACA (750 µM) inhibits glutamate-induced cytotoxicity, decreases in intracellular glutathione (GSH) levels, and increases in intracellular reactive oxygen species (ROS) levels in PC12 cells. It reduces cortical tissue damage and decreases the distance traveled to the platform in the Morris water maze in a rat model of traumatic brain injury. NACA (60 and 120 mg/kg) also inhibits ovalbumin-induced decreases in GSH, increases in nuclear NF-kappaB p65 and HIF-1alpha, and increases in IL-4, IL-5, and IL-13 levels in mouse lung tissue.Formal Name: (2R)-2-(acetylamino)-3-mercapto-propanamide. CAS Number: 38520-57-9. Synonyms: N-Acetylcysteine amide, NACA. Molecular Formula: C5H10N2O2S. Formula Weight: 162.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMSO: 50 mg/mL, Ethanol: 50 mg/mL, PBS (pH 7.2): 30 mg/mL. SMILES: SC[C@H](NC(C)=O)C(N)=O. InChi Code: InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1. InChi Key: UJCHIZDEQZMODR-BYPYZUCNSA-N.