N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid

N-acetyl-2,3-dehydro-2-Deoxyneuraminic acid (DANA) is an inhibitor of human neuraminidases (sialidases) NEU1-4 (IC50s = 143, 43, 61, and 74 µM, respectively). In vivo, DANA (30 µl of a 5 mM solution) reduces latency to first seizure and increases seizure duration in a rat model of potassium-induced seizures.Formal Name: 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid. CAS Number: 24967-27-9. Synonyms: DANA. Molecular Formula: C11H17NO8. Formula Weight: 291.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 243, 295 nm. SMILES: OC(C1=C[C@H](O)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1)=O. InChi Code: InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1. InChi Key: JINJZWSZQKHCIP-UFGQHTETSA-N.