N-(3-Hydroxydodecanoyl)-L-homoserine lactone

Quorum sensing agent. N-(3-Hydroxydodecanoyl)-L-homoserine lactone (3OH-C12-HSL) is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention and formation of biofilms. The DL-version of 3OH-C12-HSL, triggered apoptosis of bone marrow-derived macrophages through ER- and mitochondria-mediated pathways and as a virulence factor, contributed to bacterial infection and survival as well as the modification of host responses in the early stages of infection [6].