N-(2-hydroxyethyl)-Naphthalimide

N-(2-hydroxyethyl)-Naphthalimide is an N-substituted 1,8-naphthalimide used as a fluorescent probe and as a precursor for protection of amine groups. It is used to detect nucleic acids and their precursors, which quench the fluorescence of N-(2-hydroxyethyl)-naphthalimide. Nucleic acids quench the fluorescence most strongly followed by nucleosides and nucleobases, of which purine bases quench more strongly than pyrimidine bases. N-(2-hydroxyethyl)-Naphthalimide is electroactive and forms adducts with 1,3-dihydroxy benzene and 1,3,5-trihydroxybenzene. N-(2-hydroxyethyl)-Naphthalimide displays excitation spectra of 330-333 and 344-347 nm with emission spectra of 366-378 nm in solvents of varying polarities, with a higher Stokes shift in less polar solvents.Formal Name: 2-(2-hydroxyethyl)-1H-benz[de]isoquinoline-1,3(2H)-dione. CAS Number: 5450-40-8. Synonyms: N-(2-hydroxyethyl)-1,8-Naphthalimide, NSC 11547. Molecular Formula: C14H11NO3. Formula Weight: 241.2. Purity: >95%. Emission: 366-378 nm. Excitation: 330-333, 344-347 nm. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 212, 234, 332 nm. SMILES: O=C(C1=CC=CC2=C1C3=CC=C2)N(CCO)C3=O. InChi Code: InChI=1S/C14H11NO3/c16-8-7-15-13(17)10-5-1-3-9-4-2-6-11(12(9)10)14(15)18/h1-6,16H,7-8H2. InChi Key: XKPZHSCHHBRGLY-UHFFFAOYSA-N.