MTP 131 (acetate)

MTP 131 is a mitochondria-targeted peptide antioxidant. It localizes to the mitochondria and reduces tert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 nM. MTP 131 (2 mg/kg) reduces infarct volume, hemispheric swelling, and glutathione (GSH) depletion in a mouse model of acute cerebral ischemia induced by middle cerebral artery occlusion (MCAO). It increases survival, improves motor function, and decreases degeneration of the lumbar spinal cord in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 5 mg/kg. MTP 131 reduces albuminuria, urinary hydrogen peroxide levels, and mesangial matrix accumulation, as well as preserves superoxide production, in a db/db mouse model of diabetic nephropathy.Formal Name: D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, acetate. CAS Number: 1334953-95-5. Synonyms: Elamipretide, SS-31. Molecular Formula: C32H49N9O5 . XC2H4O2. Formula Weight: 639.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: CC(C=C(C=C1C)O)=C1C[C@H](NC([C@H](N)CCCNC(N)=N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O.CC(O)=O. InChi Code: InChI=1S/C32H49N9O5.C2H4O2/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21,1-2(3)4/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38),1H3,(H,3,4)/t24-,25+,26+,27+,/m1./s1. InChi Key: UEYRJRBULBAAEG-NFWUDPOKSA-N.