MTOB

Description: MTOB (alpha-keto-gamma-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal. Target: Others. Smiles: [Na+].CSCCC(=O)C([O-])=O. References: Dcona MM, Morris BL, Ellis KC, Grossman SR. CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors. Cancer Biol Ther. 2017 Jun 3,18(6):379-391. doi: 10.1080/15384047.2017.1323586. Epub 2017 May 22. PubMed PMID: 28532298, PubMed Central PMCID: PMC5536941.