MSC4381

MSC4381 is an inhibitor of monocarboxylate transporter 4 (MCT4, Ki = 0.011 µM). It selectively inhibits lactate efflux in MDA-MB-231 cells, which endogenously express high levels of MCT4, over SNU-398 cells, which endogenously express high levels of MCT1, and RT4 cells, which endogenously express MCT2 and MCT3 (IC50s = 0.001, >4, and 0.638 µM, respectively). MSC4381 (30 mg/kg) increases survival and reduces tumor volume in an MC-38 murine colorectal carcinoma model when administered in combination with an antibody targeting programmed cell death ligand 1 (PD-L1).Formal Name: 5-[2-[5-chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid. CAS Number: 2445185-57-7. Molecular Formula: C26H20ClN3O6S. Formula Weight: 538.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml, Methanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: COC1=CC(C(O)=O)=NC=C1C#CC2=CC(Cl)=CC=C2NS(C3=CC=C(OCC)C4=CC=CN=C34)(=O)=O. InChi Code: InChI=1S/C26H20ClN3O6S/c1-3-36-22-10-11-24(25-19(22)5-4-12-28-25)37(33,34)30-20-9-8-18(27)13-16(20)6-7-17-15-29-21(26(31)32)14-23(17)35-2/h4-5,8-15,30H,3H2,1-2H3,(H,31,32). InChi Key: FNBUZGRPJLEIMO-UHFFFAOYSA-N.