MRS2179 (ammonium salt hydrate)

MRS2179 is a competitive purinergic P2Y1 receptor antagonist (Kb = 102 nM). It is selective for P2Y1 over P2Y2, P2Y4, P2Y6, P2Y12, and P2Y13, as well as P2X1-4, receptors at 10 µM. MRS2179 reduces phospholipase C (PLC) activity induced by the P2Y receptor agonist 2-methylthioadenosine diphosphate (2-MeSADP, Cay-21230) with an IC50 value of 331 nM in turkey erythrocyte membranes that endogenously express high levels of the P2Y1 receptor. It inhibits platelet shape change and aggregation induced by ADP (Cay-21121) in washed isolated human platelets when used at a concentration of 10 µM. MRS2179 (50 mg/kg, i.v.) prolongs the length of tail bleeding time in mice, as well as decreases platelet thrombus formation in a mouse model of iron chloride-induced arterial thrombosis.Formal Name: 2'-deoxy-N-methyl-3'-adenylic acid, 5'-(dihydrogen phosphate), ammonium salt, hydrate. Molecular Formula: C11H17N5O9P2 . XNH3 [XH2O]. Formula Weight: 425.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 100 mM. SMILES: OP(OC[C@@H]1[C@@H](OP(O)(O)=O)C[C@H](N2C=NC3=C2N=CN=C3NC)O1)(O)=O.N.O. InChi Code: InChI=1S/C11H17N5O9P2.H3N.H2O/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19,,/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22),1H3,1H2/t6-,7+,8+,,/m0../s1. InChi Key: DEQIORFOBOEGKZ-ZJWYQBPBSA-N.