Monensin (sodium salt)

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 µg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.Formal Name: 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-beta-methoxy-alpha,gamma,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid, monosodium salt. CAS Number: 22373-78-0. Synonyms: Monensin A, NSC 343257. Molecular Formula: C36H61O11 . Na. Formula Weight: 692.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, Ethanol: 15 mg/ml. SMILES: OC[C@@]1(O)[C@H](C)C[C@H](C)[C@]([C@]2([H])O[C@]([C@]3(CC)CC[C@@]([C@@]4(C)O[C@@]5(C[C@H](O)[C@@H](C)[C@]([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)([H])O5)CC4)([H])O3)([H])[C@@H](C)C2)([H])O1.[Na+]. InChi Code: InChI=1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40,/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40),/q,+1/p-1/t19-,20-,21+,22+,23-,24-,25-. InChi Key: XOIQMTLWECTKJL-FBZUZRIGSA-M.