Monactin

Description: Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species. Target: Others. Smiles: [H][C@]12CC[C@]([H])(O1)[C@H](C)C(=O)O[C@@H](C)C[C@]1([H])CC[C@@]([H])(O1)[C@@H](C)C(=O)O[C@H](CC)C[C@@]1([H])CC[C@]([H])(O1)[C@H](C)C(=O)O[C@@H](C)C[C@]1([H])CC[C@@]([H])(O1)[C@@H](C)C(=O)O[C@H](C)C2. References: Islam MT, Laatsch H, von Tiedemann A. Inhibitory Effects of Macrotetrolides from Streptomyces spp. On Zoosporogenesis and Motility of Peronosporomycete Zoospores Are Likely Linked with Enhanced ATPase Activity in Mitochondria. Front Microbiol. 2016 Nov 18,7:1824. eCollection 2016. PubMed PMID: 27917156, PubMed Central PMCID: PMC5114239.