MMP Inhibitor II

Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP Inhibitor II is a reversible, broad-range inhibitor of MMPs. It has been reported to inhibit MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).Formal Name: hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-2-pyrimidinecarboxamide. CAS Number: 203915-59-7. Synonyms: Matrix Metalloproteinase Inhibitor II, NHDDPC, PG 117025, PGE 4410186. Molecular Formula: C21H27N3O8S2. Formula Weight: 513.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 244 nm. SMILES: COC1=CC=C(S(N2CC(C)(C)CN(S(C3=CC=C(OC)C=C3)(=O)=O)C2C(NO)=O)(=O)=O)C=C1. InChi Code: InChI=1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25). InChi Key: MCSWSPNUKWMZHM-UHFFFAOYSA-N.