ML-9

Description: ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 µM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation. Target: Akt, Myosin. Smiles: Cl.Clc1cccc2c(cccc12)S(=O)(=O)N1CCCNCC1. References: Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23,486(3):325-33.