ML-60218

Description: ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 µM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms. Target: DNA/RNA Synthesis. Smiles: Cc1c(sc2ccc(Cl)cc12)-c1cc(NS(=O)(=O)c2ccccc2Cl)n(C)n1. References: Eichwald C, et al. Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles. J Virol. 2018,92(3):e01943-17. Published 2018 Jan 17.