ML-204

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 µM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 µM.Formal Name: 4-methyl-2-(1-piperidinyl)-quinoline. CAS Number: 5465-86-1. Synonyms: CID-230710, 2-piperidino-Lepidine, NSC 25850. Molecular Formula: C15H18N2. Formula Weight: 226.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 15 mg/ml, Ethanol: 15 mg/ml. lambdamax: 212, 252, 278, 352 nm. SMILES: CC1=CC(N2CCCCC2)=NC3=CC=CC=C31. InChi Code: InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3. InChi Key: USYRQXDHKXGTCK-UHFFFAOYSA-N.