Mitoquinone (mesylate)

Mitoquinone is an oxidized form of mitoquinol (Cay-89950). It is reduced to mitoquinol in isolated bovine heart mitochondrial membranes using succinate for respiration when used at a concentration of 50 µM. Mitoquinone (0.01-10 µM) increases the rate of hydrogen peroxide formation in isolated bovine aortic endothelial cells (BAECs). It induces cell death in isolated mouse pancreatic acinar cells when used at a concentration of 1 µM. Mitoquinone, in combination with mitoquinol, reduces malondialdehyde (MDA) levels in isolated rat liver mitochondria and decreases caspase activity in Jurkat cells.Formal Name: [10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-phosphonium, monomethanesulfonate. CAS Number: 845959-50-4. Molecular Formula: C37H44O4P . CH3O3S. Formula Weight: 678.8. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol:water (1:1). Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C(C(OC)=C1OC)C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=C(C)C1=O.O=S(C)([O-])=O. InChi Code: InChI=1S/C37H44O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32,1-5(2,3)4/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3,1H3,(H,2,3,4)/q+1,/p-1. InChi Key: GVZFUVXPTPGOQT-UHFFFAOYSA-M.