MitoPQ

MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat. Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I. Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.Formal Name: 1-methyl-1'-(10-(triphenylphosphonio)decyl)-[4,4'-bipyridine]-1,1'-diium iodide. CAS Number: 1821370-28-8. Synonyms: MitoParaquat. Molecular Formula: C39H46N2P . 3I. Formula Weight: 954.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 1 mg/ml, Ethanol: 0.33 mg/ml. SMILES: C[N+](C=C1)=CC=C1C(C=C2)=CC=[N+]2CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]. InChi Code: InChI=1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39,,,/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3,3*1H/q+3,,,/p-3. InChi Key: AOZZGHKENAZYTD-UHFFFAOYSA-K.