Mibefradil

Description: Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 µM and 18.6 µM for T-type and L-type currents). Target: Calcium Channel. Smiles: C(CN(CCCC=1NC=2C(N1)=CC=CC2)C)[C@]3(OC(COC)=O)[C@@H]([C@@H](C)C)C=4C(CC3)=CC(F)=CC4. References: Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec,271(3):1483-8.