Methylcobalamin

Methylcobalamin is an analog of vitamin B12 (Cay-18425) with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 µM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Cay-11764) in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.Formal Name: co-methyl-cobinamide, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3). CAS Number: 13422-55-4. Synonyms: Algobaz, Co-Methylcobalamin, Mecobalamin, MeCbl, Methyl Vitamin B12. Molecular Formula: C63H91CoN13O14P. Formula Weight: 1344.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 265 nm. SMILES: [CH3-][Co+3]123([N]4=CN([C@@H](O[C@H](CO)[C@H]5O[P]6([O-])=O)[C@]5([H])O)C7=C4C=C(C)C(C)=C7)[N]8=C9[C@@H](CCC(N)=O)[C@@](CC(N)=O)(C)[C@]8(C)[C@@]([C@H](CC(N)=O)[C@]%10(CCC(NC[C@@H](C)O6)=O)C)([H])[N-]1C%10=C(C)C([C@@H](CCC(N)=O)C%11(C)C)=[N]2C%11=CC%12=[N]3C([C@@](C)(CC(N)=O)[C@@H]%12CCC(N)=O)=C9C. InChi Code: InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56,,/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86),1H3,/q,-1,+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56+,57+,59-,60+,61+,62+,,/m1../s1. InChi Key: ZFLASALABLFSNM-WDJKBINPSA-L. Origin: Bacterium/Pseudomonas denitrificans.