Methocarbamol

Methocarbamol is an orally bioavailable skeletal muscle relaxant. In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg. It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg. Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 µM, respectively). Formulations containing methocarbamol have been used to treat skeletal muscle spasms.Formal Name: 3-(2-methoxyphenoxy)-1,2-propanediol, 1-carbamate. CAS Number: 532-03-6. Synonyms: AHR 85, Guaiacol Glyceryl Ether Carbamate, Guaiphenesin Carbamate, NSC 170960. Molecular Formula: C11H15NO5. Formula Weight: 241.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMF:PBS (pH7.2) (1:30): 0.03 mg/ml, DMSO: 16 mg/ml, Ethanol: 14 mg/ml. lambdamax: 230, 273 nm. SMILES: COC1=C(OCC(O)COC(N)=O)C=CC=C1. InChi Code: InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14). InChi Key: GNXFOGHNGIVQEH-UHFFFAOYSA-N.