Memantine (hydrochloride)

Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 µM. It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro. In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3beta and amyloid-beta (Abeta) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer's disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats. It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.Formal Name: 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride. CAS Number: 41100-52-1. Synonyms: Akatinol, Axura, Ebix, Namenda, NSC 102290, SUN Y7017. Molecular Formula: C12H21N . HCl. Formula Weight: 215.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: N[C@]12C[C@](C[C@@](C)(C2)C3)(C)C[C@@H]3C1.Cl. InChi Code: InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10,/h9H,3-8,13H2,1-2H3,1H/t9-,10+,11-,12-,. InChi Key: LDDHMLJTFXJGPI-VXMZOEJHSA-N.