Mefloquine (hydrochloride)

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties. It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites. It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis. Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior. Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.Formal Name: rel-alphaS-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, monohydrochloride. CAS Number: 51773-92-3. Synonyms: NSC 157387, Ro 21-5998/001. Molecular Formula: C17H16F6N2O . HCl. Formula Weight: 414.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 210, 222 nm. SMILES: O[C@H]([C@]1([H])NCCCC1)C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C32.Cl. InChi Code: InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11,/h3-5,8,12,15,24,26H,1-2,6-7H2,1H/t12-,15+,/m1./s1. InChi Key: WESWYMRNZNDGBX-YLCXCWDSSA-N.