Meclofenoxate (hydrochloride)

Meclofenoxate is a nootropic agent. It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson's disease. It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson's disease when administered at a dose of 100 mg/kg. Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats. It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice. Formulations containing meclofenoxate have been used in the treatment of senile dementia.Formal Name: 2-(4-chlorophenoxy)-acetic acid, 2-(dimethylamino)ethyl ester, monohydrochloride. CAS Number: 3685-84-5. Synonyms: Dimethylaminoethyl 4-chlorophenoxyacetate, Methocynal. Molecular Formula: C12H16ClNO3 . HCl. Formula Weight: 294.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 33 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 226, 280, 288 nm. SMILES: ClC1=CC=C(OCC(OCCN(C)C)=O)C=C1.Cl. InChi Code: InChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11,/h3-6H,7-9H2,1-2H3,1H. InChi Key: FIVHOHCAXWQPGC-UHFFFAOYSA-N.