M2N12

M2N12 is a clickable inhibitor of cell division cycle 25 (Cdc25, IC50s = 0.53, 1.39, and 0.09 µM for Cdc25A, Cdc25B, and Cdc25C, respectively). It is composed of a naphthoquinone derivative functionalized with a clickable cyclic azide group. M2N12 inhibits the proliferation of A549 lung cancer and MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 3.92, 4.63, and 4.71 µM, respectively).Formal Name: 6-chloro-7-[[[1-[(4-methylphenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-5,8-quinolinedione. CAS Number: 2376577-06-7. Molecular Formula: C20H16ClN5O2. Formula Weight: 393.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. SMILES: O=C1C(Cl)=C(C(C2=NC=CC=C12)=O)NCC3=CN(CC4=CC=C(C)C=C4)N=N3. InChi Code: InChI=1S/C20H16ClN5O2/c1-12-4-6-13(7-5-12)10-26-11-14(24-25-26)9-23-18-16(21)19(27)15-3-2-8-22-17(15)20(18)28/h2-8,11,23H,9-10H2,1H3. InChi Key: BDBIMDYALUJAPR-UHFFFAOYSA-N.