LY2183240

LY2183240 is a potent, competitive inhibitor of anandamide uptake (IC50 = 270 pM, Ki = 540 pM) and hydrolysis. It increases anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain.Formal Name: 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide. CAS Number: 874902-19-9. Molecular Formula: C17H17N5O. Formula Weight: 307.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 2 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.1 mg/ml. lambdamax: 253 nm. SMILES: O=C(N(C)C)N1N=NN=C1CC2=CC=C(C3=CC=CC=C3)C=C2. InChi Code: InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3. InChi Key: GZNIYOXWFCDBBJ-UHFFFAOYSA-N.