Lucidenic Acid A

Lucidenic acid A is a triterpene originally isolated from G. lucidum and has anticancer activity. It is cytotoxic to HepG2, HepG2 2.2.15', and P388 cancer cells (IC50s = 0.164, 0.205, and 17 nM, respectively). Lucidenic acid A inhibits increases in matrix metalloproteinase-2 (MMP-2) and MMP-9 activity and Matrigel(TM) invasion induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in HepG2 cells.Formal Name: (5alpha,7beta)-7-hydroxy-4,4,14-trimethyl-3,11,15-trioxo-chol-8-en-24-oic acid. CAS Number: 95311-94-7. Synonyms: Lucideric Acid A, Lucidenic Acid alpha. Molecular Formula: C27H38O6. Formula Weight: 458.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble. SMILES: O=C(C[C@]1([H])[C@@H](CCC(O)=O)C)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)[C@](C[C@@H]3O)([H])C(C)(C)C(CC4)=O. InChi Code: InChI=1S/C27H38O6/c1-14(7-8-21(32)33)15-11-20(31)27(6)23-16(28)12-18-24(2,3)19(30)9-10-25(18,4)22(23)17(29)13-26(15,27)5/h14-16,18,28H,7-13H2,1-6H3,(H,32,33)/t14-,15-,16+,18+,25+,26-,27+/m1/s1. InChi Key: INIPQDKLXQHEAJ-NCQSLMINSA-N. Origin: Fungus/Ganoderma sp..