LRE1

An allosteric inhibitor of soluble adenylyl cyclase (IC50 = 50 = 11 µM), inhibits the activity of mitochondrial complex IV in wild-type but not sAC knockout MEFs at 50 µM, reduces ischemia and reperfusion-induced swelling of, and ATP content decreases in, rat liver mitochondria at 1.2 mg/kg. Formulation: A solid. InChI: InChI=1S/C12H13ClN4S/c13-10-6-11(16-12(14)15-10)17(8-3-4-8)7-9-2-1-5-18-9/h1-2,5-6,8H,3-4,7H2,(H2,14,15,16). InChIKey: PDWZXKSZLRVSEH-UHFFFAOYSA-N. SMILES: NC1=NC(Cl)=CC(N(CC2=CC=CS2)C3CC3)=N1