Losartan (potassium salt)

Losartan is an antagonist of angiotensin II type 1b (AT1b) receptor (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor). It reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma when used at a concentration of 5 µM. It decreases 1-lipoxygenase (1-LO) levels in the endothelial layer of autologous vein grafts in rabbits fed a high-cholesterol diet when administered at a dose of 10 mg/kg per day. Losartan (15 mg/kg per day) decreases systolic blood pressure in a ouabain-induced mouse model of hypertension. It also increases the mechanical pain threshold in the von Frey test in a paclitaxel-induced rat model of neuropathic pain when administered at a dose of 50 mg/kg twice per day. Formulations containing losartan have been used in the treatment of hypertension and diabetic nephropathy.Formal Name: 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt. CAS Number: 124750-99-8. Synonyms: DuP-753, MK 954. Molecular Formula: C22H22ClN6O . K. Formula Weight: 461.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4.[K+]. InChi Code: InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22,/h4-7,9-12,30H,2-3,8,13-14H2,1H3,/q-1,+1. InChi Key: OXCMYAYHXIHQOA-UHFFFAOYSA-N.