Lopinavir

Lopinavir is a potent HIV-1 protease inhibitor (Ki = 1.3 pM for wild-type enzyme). It inhibits the replication of clinical isolates of HIV-1 (EC50s = 5-52 nM). Lopinavir reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, EC50s = 26.63 and 26.10 µM, respectively). It reduces lung and kidney viral load, bronchointerstitial pneumonia, and pulmonary inflammatory cell infiltration in a marmoset model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered in combination with ritonavir (Cay-13872).Formal Name: N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alphaS-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide. CAS Number: 192725-17-0. Synonyms: A-157378.0, ABT-378. Molecular Formula: C37H48N4O5. Formula Weight: 628.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 14 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 259 nm. SMILES: O=C(N[C@H](C[C@H](O)[C@@H](NC(COC(C(C)=CC=C1)=C1C)=O)CC2=CC=CC=C2)CC3=CC=CC=C3)[C@@H](N(CCCN4)C4=O)C(C)C. InChi Code: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34. InChi Key: KJHKTHWMRKYKJE-SUGCFTRWSA-N.