Lomustine

Lomustine is a nitrosourea DNA alkylating agent that forms DNA interstrand crosslinks and strand breaks. It reduces tumor volume in a melanoma mouse xenograft model when administered at doses ranging from 4 to 16 mg/kg. Formulations containing lomustine have been used in the treatment of various cancers in human and veterinary medicine.Formal Name: N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-urea. CAS Number: 13010-47-4. Synonyms: CCNU, NCI C04740, NSC 79037. Molecular Formula: C9H16CIN3O2. Formula Weight: 233.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM, Water: 25 mM. lambdamax: 230 nm. SMILES: O=C(N(N=O)CCCl)NC1CCCCC1. InChi Code: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14). InChi Key: GQYIWUVLTXOXAJ-UHFFFAOYSA-N.