Linderane

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 µM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.Formal Name: (1aS,4E,10S,10aS)-3,6,10,10a-tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one. CAS Number: 13476-25-0. Molecular Formula: C15H16O4. Formula Weight: 260.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:10): 0.09 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 213 nm. SMILES: CC1=COC2=C1[C@@](OC3=O)([H])[C@@H](O4)C34CC/C=C(C)\C2. InChi Code: InChI=1S/C15H16O4/c1-8-4-3-5-15-13(19-15)12(18-14(15)16)11-9(2)7-17-10(11)6-8/h4,7,12-13H,3,5-6H2,1-2H3/b8-4-/t12-,13+,15?/m0/s1. InChi Key: KBMSVODXFLAQNJ-JELGAPFCSA-N.