Licochalcone A

Licochalcone A is a natural chalcone first identified in roots and rhizomes of licorice (Glycyrrhiza spp.). It has anti-inflammatory actions, supporting its use as a skin lightening agent, particularly for rosacea and atopic dermatitis. Licochalcone A (10-50 µM) induces apoptosis and suppresses migration and invasion of cancer cells in vitro. It also has antibacterial properties against spore-forming bacteria (MIC = 2-15 µg/ml) and anti-parasitic actions (IC50 = 2 µg/ml).Formal Name: (2E)-3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one. CAS Number: 58749-22-7. Molecular Formula: C21H22O4. Formula Weight: 338.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 20 mg/ml. lambdamax: 212, 252, 315, 377 nm. SMILES: OC1=CC=C(C(/C=C/C2=C(OC)C=C(O)C(C(C)(C)C=C)=C2)=O)C=C1. InChi Code: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+. InChi Key: KAZSKMJFUPEHHW-DHZHZOJOSA-N. Origin: Plant/Glycyrrhiza glabra.