Liarozole

Description: Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative, it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders. Target: Retinoid Receptor, P450. Smiles: Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1. References: Bryson HM, et al. Liarozole. Drugs Aging. 1996 Dec,9(6):478-84, discussion 485.