Leuprorelin (acetate)

Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) receptor agonist. It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. Formulations containing leuprorelin have been used in the treatment of hormone-dependent prostate and breast cancers, endometriosis, and precocious puberty.Formal Name: 6-D-leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), monoacetate. CAS Number: 74381-53-6. Molecular Formula: C59H84N16O12 . C2H4O2. Formula Weight: 1269.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 222, 276 nm. SMILES: O=C([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CNC=N3)NC([C@@H]4CCC(N4)=O)=O)=O)N[C@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](C(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(NCC)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)=O)CO.OC(C)=O. InChi Code: InChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40,1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64),1H3,(H,3,4)/t. InChi Key: RGLRXNKKBLIBQS-XNHQSDQCSA-N.