Lapachol

Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities. It is larvicidal against T. canis when used at a concentration of 2 mg/ml. Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells. It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml. Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis. It also reduces carrageenan-induced paw edema and abscess formation in rats.Formal Name: 2-hydroxy-3-(3-methyl-2-buten-1-yl)-1,4-naphthalenedione. CAS Number: 84-79-7. Synonyms: C.I. 75490, NSC 11905, NSC 629756. Molecular Formula: C15H14O3. Formula Weight: 242.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 10mg/mL, Ethanol: 1mg/mL. lambdamax: 253, 282 nm. SMILES: O=C1C(C/C=C(C)/C)=C(O)C(C2=CC=CC=C21)=O. InChi Code: InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,18H,8H2,1-2H3. InChi Key: CIEYTVIYYGTCCI-UHFFFAOYSA-N. Origin: Synthetic.