L-Valacyclovir (hydrochloride)

L-Valacyclovir is the L-valyl prodrug of acyclovir (Cay-14160), an antiviral compound. L-Valacyclovir inhibits herpes simplex virus type I (HSV-I) replication (IC50 = 0.84 µM in Vero cells). It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo. Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.Formal Name: 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, L-valine, monohydrochloride. CAS Number: 124832-27-5. Synonyms: BW 256U, BW 256U87. Molecular Formula: C13H20N6O4 . HCl. Formula Weight: 360.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 3 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: NC(NC1=C2N=CN1COCCOC([C@@H](N)C(C)C)=O)=NC2=O.Cl. InChi Code: InChI=1S/C13H20N6O4.ClH/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20,/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20),1H/t8-,/m0./s1. InChi Key: ZCDDBUOENGJMLV-QRPNPIFTSA-N.