L-Valacyclovir-d8 (hydrochloride)

L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir (Cay-23801) by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir (Cay-14160). L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 µM in Vero cells). It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo. Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.Formal Name: L-valine-2,3,4,4,4,4',4',4'-d8, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, monohydrochloride. CAS Number: 1279033-32-7. Molecular Formula: C13H12D8N6O4 . HCl. Formula Weight: 368.8. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 3 mg/ml, Ethanol: Insolule, PBS (pH 7.2): 10 mg/ml. SMILES: NC(NC1=C2N=CN1COCCOC([C@](N)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=NC2=O.Cl. InChi Code: InChI=1S/C13H20N6O4.ClH/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20,/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20),1H/t8-,/m0./s1/i1D3,2D3,7D,8D,. InChi Key: ZCDDBUOENGJMLV-HVFXBKHYSA-N.