L-Quisqualic Acid

L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4, Ki = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.Formal Name: alphaS-amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid. CAS Number: 52809-07-1. Molecular Formula: C5H7N3O5. Formula Weight: 189.1. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: Water: 25 mM. SMILES: O=C1NC(N(C[C@@H](C(O)=O)N)O1)=O. InChi Code: InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1. InChi Key: ASNFTDCKZKHJSW-REOHCLBHSA-N.