L-Pipecolic Acid

L-Pipecolic acid is a metabolite of the amino acid L-lysine. L-Pipecolic acid is oxidized to L-alpha-aminoadipic acid by alpha-aminoadipic semialdehyde dehydrogenase (alpha-AASA dehydrogenase) and peroxisomal sarcosine oxidase (PSO). L-Pipecolic acid inhibits GABA binding in bovine brain homogenate in the presence, but not absence, of hexobarbital or pentobarbital (IC50s = 0.2 and 2 nM, respectively). Serum levels of L-pipecolic acid are elevated in patients with Zellwager syndrome, a peroxisomal condition characterized by hepatomegaly, abnormal facial features, and cognitive impairments.Formal Name: 2S-piperidinecarboxylic acid. CAS Number: 3105-95-1. Synonyms: (S)-Piperidine-2-Carboxylic Acid, L-Homoproline, NSC 93089. Molecular Formula: C6H11NO2. Formula Weight: 129.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: OC([C@@H]1CCCCN1)=O. InChi Code: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1. InChi Key: HXEACLLIILLPRG-YFKPBYRVSA-N.