L-AP4

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 µM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.Formal Name: 2S-amino-4-phosphono-butanoic acid. CAS Number: 23052-81-5. Synonyms: L-(+)-2-amino-4-phosphorobutanoic acid, L-APB. Molecular Formula: C4H10NO5P. Formula Weight: 183.1. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 2 mg/ml. SMILES: OP(CC[C@@H](C(O)=O)N)(O)=O. InChi Code: InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10). InChi Key: DDOQBQRIEWHWBT-UHFFFAOYSA-N.