L-Alanosine

Description: L-Alanosine inhibits adenylosuccinate synthetase. L-Alanosine is an antibiotic from Streptomyces alanosinicus with antineoplastic activity. L-Alanosine blocks the common de novo purine biosynthesis pathway and, thereby, inhibit tumor cells with MTAP deficiency. Target: Others. Smiles: N[C@@H](CN(O)N=O)C(O)=O. References: Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15,66(4):613-21.