L-902688

Description: L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM, EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors. Target: Prostaglandin Receptor. Smiles: C(=C/[C@H](C(F)(F)C1=CC=CC=C1)O)\[C@@H]2N(CCCCCCC=3NN=NN3)C(=O)CC2. References: Lai YJ, et al. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Mar 3,19(3). pii: E727.